Free Radic Biol Med 1997; 23: 134–47 PubMedCrossRef 5 Adams JD,

Free Radic Biol Med 1997; 23: 134–47.PubMedCrossRef 5. Adams JD, Odunze IN. Review: oxygen free radicals and Parkinson’s disease. IKK inhibitor Free Radic Biol Med 1991; 10: 161–9.PubMedCrossRef 6. Doeppner TR, Hermann DM. Free radical scavengers and spin traps — therapeutic

implications for ischemic stroke. Best Pract Res Clin Anaesthesiol 2010; 24: 511–20.PubMedCrossRef 7. The Edaravone Acute Brain Infarction Study Group. Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction: randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis 2003; 15: 222–9.CrossRef 8. Feng S, Yang Q, Liu M, et al. Edaravone for acute ischaemic stroke (review). Cochrane Database Syst Rev 2011; (12): CD007230.PubMed 9. Yang J, Liu M, Zhou J, et al. Edaravone for acute intracerebral haemorrhage (review). Cochrane Database Syst Rev 2011;(2):CD007755. 10. Mao YF, Yan N, Xu H, et al. Edaravone, a free radical scavenger, is effective on neuropathic pain in rats. Brain Res 2009; 1248: 68–75.PubMedCrossRef 11. Yoshida H, Yanai H, Namiki Y, et al. Neuroprotective effects of edaravone: a novel free radical SAHA scavenger in cerebrovascular injury.

CNS Drug Rev 2006; 12: 9–20.PubMedCrossRef 12. Takeda T, Takeda S, Takumida M, et al. Protective effects of edaravone against ischemia-induced facial palsy. Auris Nasus Larynx 2007; 35: 321–7.PubMedCrossRef 13. Ishizawa M, Mizushige K, Noma T, et al. An antioxidant treatment potentially protects myocardial energy metabolism by regulating uncoupling protein 2 expression in a chronic beta-adrenergic stimulation Ubiquitin inhibitor rat model. Life Sci 2006; 78: 2974–82.PubMedCrossRef 14. Zhang N, Komine-Kobayashi M, Tanaka R, et al. Edaravone reduces early accumulation of oxidative products and sequential inflammatory responses after transient focal ischemia in mice brain. Stroke 2005; 36: 2220–5.PubMedCrossRef 15. Moriya M, Nakatsuji Y, Miyamoto K, et al. Edaravone, a free

radical scavenger, ameliorates experimental autoimmune encephalomyelitis. Neurosci Lett 2008; 440: 323–6.PubMedCrossRef 16. Kikucki K, Uchikado H, Miyagi N, et al. Beyond neurological disease: new targets for edaravone (review). Int J Mol Med 2011; 28: 899–906. GNA12 17. Sano H, Kamijo T, Ino T, et al. Edaravone, a free radical scavenger, in the treatment of idiopathic sudden sensorineural hearing loss with profound hearing loss. Auris Nasus Larynx 2010; 37: 42–6.PubMedCrossRef 18. Higashi Y, Jitsuiki D, Chayama K, et al. Edaravone (3-me-thyl-1-phenyl-2-pyrazolin-5-one), a novel free radical scavenger, for treatment of cardiovascular diseases. Recent Pat Cardiovasc Drug Dis 2006; 1: 85–93.CrossRef 19. Gu LQ, Xin YF, Zhang S, et al. Determination of edaravone in plasma of beagle dog by LC-MS. Zhejiang Provincial Academy of Medical Sciences 2010; 21: 24–7. 20. Shibata H, Arai S, Izawa M, et al.

Comments are closed.