Thirty-seven patients received a total of 112 FEIBA treatment courses, 90 for acute bleeding and 22 for surgical haemostasis. The median FEIBA dose per

infusion for acute bleeding was 50 IU kg−1, and for surgery was 100 IU kg−1. For both acute joint and muscle/soft tissue bleeding and in surgery, haemostasis was attained in a median of two FEIBA infusions. FEIBA was judged effective in 92% of treatment courses for acute bleeding, with a 95% confidence interval (CI) of 85–97%. Rates of haemostatic efficacy did not differ significantly between anatomical sites of acute bleeding. The haemostatic efficacy rate of FEIBA in surgery was 86% (CI, 65–97%). No thromboembolic complications or other adverse selleck events occurred during any treatment course. FEIBA has been successfully integrated into clinical practice in Turkey, with rates of haemostatic efficacy comparable Venetoclax cost to those reported in countries with a longer history of FEIBA usage. “
“Due to an increased life expectancy, besides hemophilia-related comorbidity (e.g. arthropathy, hepatitis C and human immunodeficiency virus infection) nonhemophilia-related medical problems are seen increasingly in hemophilia patients. Treatment recommendations and psychosocial consequences in aging hemophilia patients are discussed. While hypertension is reported to occur more often in hemophilia patients than in the general

population, mortality from cardiovascular disease is lower, although the incidence is increasing. Despite having a higher risk profile, the incidence of myocardial infarction is also lower, especially in severe hemophilia. General indications for Farnesyltransferase cardiac intervention can be applied to hemophilia patients. Treatment of ischemic heart disease using adequate clotting factor concentrate (CFC) correction in combination with an adapted anticoagulant and antiplatelet therapeutical schedule should be tailored to the individual patient, depending on the clinical situation. Recommendations are given on dealing with tooth extraction, surgical intervention,

and sexuality problems in patients with hemophilia. In addition to hemophilia in itself, comorbidity has a major psychological impact, and important effects on sexuality and quality of life. It can also result in complex treatment regimens, in which coordination among healthcare workers is essential. “
“Summary.  The most common bleeding in haemophilic patients is in joints, and joint disability is the most common complications in these patients receiving inadequate treatment. Limited by economy and inadequate treatment, developing countries face huge challenge to reduce disability and improve quality of life (QoL) of haemophilic children. The aim of this study was to investigate the effect of low dose secondary prophylaxis in China.