The frequencies of DRB1*04, *13*14 alleles were increased in Uyghur UC patients compared with normal controls. The frequency of DRB1*08 was decreased in Uyghur UC patients compared selleck chemical with normal controls. Polymorphism of the HLA-DRB1 gene may contribute to the clinical heterogeneity of UC between Han and Uyghur UC patients in China. CONCLUSION: HLA-DRB1*04*13*14 and DRB1*08 may contribute to the clinical heterogeneity of UC between Han and Uyghur UC patients. Keywords: Ulcerative colitis, DRB1* gene polymorphisms, Han and Uyghur Core tip: This study evaluated the association between HLA-DRB1 alleles and Han and Uyghur ulcerative colitis (UC) patients residing in the Xinjiang Uyghur Autonomous Region of China. The authors found that polymorphism of the HLA-DRB1* gene differed between the Han and Uyghur patients with UC.
Polymorphism of the HLA-DRB1 gene may contribute to the clinical heterogeneity of UC between Han and Uyghur UC patients in North-West China. INTRODUCTION Ulcerative colitis (UC) and Crohn��s disease are often grouped together as inflammatory bowel disease (IBD). IBD is the term used to describe idiopathic disorders associated with chronic inflammation of the gastrointestinal tract[1,2]. Clinical features common to both disorders include abdominal pain, diarrhea, weight loss, and increased risk of developing colorectal cancer[3,4]. The etiology of UC is still not known. However, underlying genetic, environmental, and lifestyle issues can affect an individual��s predisposition to these diseases[5,6].
Genetic factors involved in the regulation of the immune system are thought to play a significant role in the pathogenesis of UC[7]. Human leukocyte antigens (HLA), located on chromosome 6, play an important role in the immune response and several immune-mediated diseases. Several studies have shown that HLA alleles are associated with UC[8]. We previously compared the clinical characteristics of UC in the Han and Uyghur populations residing in the Xinjiang Uyghur Autonomous Region of China. We showed some differences between the Uyghur and Han populations living in the same region, which included a higher prevalence of UC, a younger age of onset, an increased prevalence of the chronic persistent and acute outbreak type, more moderate and severe forms, a higher complication rate, and an increased frequency of positive antineutrophilic cytoplasmic antibodies (ANCA) in the Uyghur population[9].
However, to date, Hardly a research shows that there is association between HLA-DRB1 alleles and UC in the Uyghur population. It would be interesting to know what causes the clinical heterogeneity of UC between Han and Uyghur UC patients in China. MATERIALS AND METHODS Patients and controls Consecutive patients with UC were recruited Anacetrapib from the Department of Gastroenterology, Xinjiang People��s Hospital of China.