CrossRefPubMed 23 Weaver BA, Cleveland DW: Decoding the links be

CrossRefPubMed 23. Weaver BA, Cleveland DW: Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death. Cancer Cell 2005, 8 (1) : 7–12.CrossRefPubMed 24. Dey P: Aneuploidy and malignancy: an unsolved equation. J Clin Pathol 2004, 57 (12) : 1245–1249.CrossRefPubMed 25. Babu JR, Jeganathan KB, Baker DJ, Wu X, Kang-Decker N, van Deursen JM:

Rae1 is an essential mitotic checkpoint selleck chemicals regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol 2003, 160 (3) : 341–353.CrossRefPubMed 26. Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, Kumar R, Jenkins RB, de Groen PC, Roche P, van Deursen JM: BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet 2004, 36 (7) : 744–749.CrossRefPubMed 27. Sotillo R, Hernando E, Diaz-Rodriguez E, Teruya-Feldstein J, Cordon-Cardo C, Lowe SW, Benezra R: Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 2007, 11 (1) : 9–23.CrossRefPubMed 28. Shichiri M, Yoshinaga K, Hisatomi H, Sugihara K, Hirata Y: Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. Cancer Res 2002, 62 (1) : 13–17.PubMed 29. Gemma BMN 673 price A, Hosoya Y, Seike M, Uematsu K, Kurimoto F, Hibino S, Yoshimura A, Shibuya M, Kudoh S, Emi M: Genomic

structure of the human MAD2 gene and mutation analysis in human lung and breast cancers. Lung Cancer 2001, 32 (3) : 289–295.CrossRefPubMed 30. Hanks S, Coleman K, Reid S, Plaja A, Firth H, Fitzpatrick D, Kidd A, Mehes K, Nash R, Robin N, Shannon N, Tolmie J, Swansbury J, Irrthum A, Douglas J, Rahman N: Constitutional aneuploidy and cancer predisposition caused 4-Aminobutyrate aminotransferase by biallelic mutations in BUB1B. Nat Genet 2004, 36 (11) : 1159–1161.CrossRefPubMed 31. Tanudji M, Shoemaker J, L’Italien L, Russell L, Chin G, Schebye XM: Gene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes

after a mitotic delay. Mol Biol Cell 2004, 15 (8) : 3771–3781.CrossRefPubMed 32. Weaver BA, Silk AD, Montagna C, Verdier-Pinard P, Cleveland DW: Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 2007, 11 (1) : 25–36.CrossRefPubMed 33. Liu ST, URMC-099 purchase Hittle JC, Jablonski SA, Campbell MS, Yoda K, Yen TJ: Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis. Nat Cell Biol 2003, 5 (4) : 341–345.CrossRefPubMed Competing interests The authors declare that they have no competing interests. Authors’ contributions ZL participated in study design, carried out most of the experiments, and drafted the manuscript. KL participated collecting samples, and participated in manuscript preparation. XW participated in study design and revised the manuscript. JC participated in study design and revised the manuscript. BL participated in the critical revision of the manuscript.

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