This implies the product is tunable. The particle habit was needle-shaped. Two miscible fluids were used as the solvent (DMSO) and antisolvent (water). The effect of process pressure (determining the energy input), the NFN concentration, the supersaturation

ratio, and the presence of surfactant on the particle size and the crystallized material was investigated. Higher pressures resulted in smaller particle sizes, as did lowering NFN concentration and supersaturation ratios. The surfactant that was Inhibitors,research,lifescience,medical used (Solutol) did not affect the particle size. The crystalline structure was not affected by the shear rate of the process. It was identical to those formed in a beaker under low shear conditions. However, the crystallite size of the material decreased threefold from no shear to high shear conditions. CBZ was selected as a model system since it is known to exhibit polymorph multiplicity. Several solvents and antisolvents were Inhibitors,research,lifescience,medical used to determine their effect on the crystalline structure and particle size. CBZ is also known

to form hydrates, therefore both aqueous and nonaqueous solvent/antisolvent systems were used for comparison. Inhibitors,research,lifescience,medical They were Dichloromethane (DCM)/Hexane, Poly(ethylene-glycol) (PEG) 300/Water, and BMS-907351 mw Dimethyl sulfoxide (DMSO)/Water. The results obtained with respect to processing conditions are consistent with those of the NFN study. Particle sizes obtained with all bottom up experiments were consistently in the range of 250–320nm. Unfortunately, the results obtained with respect to polymorph selectivity

were not Inhibitors,research,lifescience,medical as definitive. What was observed is that the solvent/antisolvent system does matter, but it is unclear if the degrees of supersaturation or processing intensity had significant roles in that study. Inhibitors,research,lifescience,medical Three different morphologies were detected via XRD patterns and a hypothesis is given to explain the detailed observations presented there. Although not conclusive and thus more thorough studies must be performed, the explanations are consistent with those results. Although the emphasis in the previous paragraphs was in crystallization, other processes can be used to manufacture nanosized not materials with tailored properties. Encapsulation of functional ingredients in polymers is another method, which will be discussed in more detail in the sections that follow. Table 2 summarizes the processes used in the bottom up production of nanoparticles and the properties controlled via such methodologies. Table 2 List of various “bottom up” processes and influence on particle properties. 2.2. Simultaneous Targeting/Delivery Techniques Creative advances in nanotechnologies, coupled with systems biology, has led to novel chaperone systems for simultaneous targeting/delivery, and in certain instances, enhanced controlled release strategies.