Therapies targeting CX3CL1 may treat serotonin related mood disorders, including depression experienced by patients with compromised immune systems. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.”
“Plant reproduction depends on pollen dispersal. For anemophilous (wind-pollinated) species, such as grasses and many trees, shedding pollen from the anther must be accomplished by physical mechanisms. The unknown nature of this process has led to its
description as the ‘paradox of pollen liberation’. A simple scaling analysis, supported by experimental measurements on typical wind-pollinated plant species, is used to estimate the suitability of previous resolutions of this paradox based on wind-gust aerodynamic models of fungal-spore liberation. According to this scaling analysis, the steady Stokes drag force is found to be large enough to liberate anemophilous pollen grains, and unsteady boundary-layer Cl-amidine research buy forces produced by wind gusts are found to be mostly ineffective since the ratio of the characteristic viscous time scale to the inertial time scale of acceleration of the wind stream is a small parameter for typical anemophilous species. A hypothetical model of a stochastic aeroelastic mechanism, initiated by the atmospheric turbulence typical of the micrometeorological conditions in the vicinity of the plant, selleck compound is proposed to contribute
to wind pollination. (C) 2009 Elsevier Ltd. All rights reserved.”
“There is evidence check details of structural and functional deterioration in the brain, including the prefrontal cortex (PFC) and hippocampus, during the normal
aging process in animals and humans. Extracellular matrix-associated glycoproteins, such as chondroitin sulfate proteoglycans (CSPGs), are involved in not only maintaining the structures and functions of adult neurons, but also regulating the proliferation, migration, and neurite outgrowth of neural stem cells in the brain. On the other hand, a herbal medicine, yokukansan (YKS), is used in a variety of clinical situations for treating symptoms associated with age-related neurodegenerative disorders such as Alzheimer’s disease, but its pharmacological properties have not been fully understood. The present study was designed to clarify the influence of aging and the improving effects of YKS on the expression of aggrecan, a major molecule of CSPGs, and on the proliferation and migration of neural stem/progenitor cells identified by bromodeoxyuridine (BrdU) incorporation in the PFC and hippocampus including the dentate gyrus. Aged rats (24 months old) showed a significant increase in aggrecan expression throughout the PFC and in the hippocampus particularly in the CA3 subfield, but not the dentate gyrus compared to young rats (5 months old), evaluated by the immunohistochemical method. YKS treatment decreased the age-related increase in aggrecan expression as well as normal expression in young rats.