The right hemisphere

lesion group displayed an ability to process temporal information but not spectral. Behroozmand et al. (2012) produced data that further supported this idea when examining +200 cent shifts during and auditory feedback task of self-vocalization, complex tones and pure tones with missing fundamental. Zatorre (1988) showed that patients with right surgical excisions of the right auditory cortex (left intact) are impaired at perceiving pitch in complex tones with missing fundamental. Furthermore, in a pitch Alpelisib molecular weight discrimination task, patients with right but not left temporal lobe excisions showed significantly elevated thresholds for directional changes of pitch (Johnsrude et al., 2000). Increased communication between these two regions during a shift could be the result of fine-tuning necessary during error detection that is not needed for vocalization without error. Our analysis Gefitinib purchase indicated that the detection of an error resulted in the presence of a feedback loop between right IFG and right STG. This change in coupling properties indicates the need for these regions in the right hemisphere in error detection during voice production

and further fine-tuning of the actual execution of the motor command. Studies have shown that connections between IFG and STG specifically, are important to pitch processing and are therefore necessary in the detection and correction of errors in vocal performance. The neural network for pitch processing, which includes the pars triangularis of Broca’s area and the right superior temporal gyrus (STG), plays a vital role in melodic and lexical pitch processing (Nan & Friederici, 2012). Evidence that pitch processing is similar for both tonal speech and music supports the idea that IFG plays a large role in pitch processing

regardless of Ribonucleotide reductase modality and could be consistent with the link between right STG and right IFG (Nan & Friederici, 2012). Additionally, support for increased activity between these regions stems from work examining song where a predominance of right IFG contribution to melody is thought to be due to elongated vowels (Merrill et al., 2012). Finally, Tourville et al. observed increased activation of IFG during shift vs. no shift of the F1. Authors concluded that IFG was responsible for additional processing of sensorimotor information in response to error detection (STG). Our findings support this conclusion. In our model, the connection left STG to left IFG as well as left IFG to left PMC is present in both shift and no shift conditions. Similar to the right hemisphere, the presence of an unexpected pitch shift resulted in a feedback loop from left PMC to left IFG.