The parameters between two groups were compared by Chi-square test or T test and Logistic regression Palbociclib in vitro analysis was applied to analyze the risk factors of case group. Results: Univariate analysis and multivariate Logistic regression analysis revealed that abdominal circumference (OR = 1.178; 95%CI 1.08–1.28), daily calories intake (OR = 1.007; 95%CI 1.00–1.01), daily fat intake (OR = 1.175; 95%CI 1.11–1.24), increased diastolic blood pressure (OR = 1.074; 95%CI 1.02–1.13), diabetes mellitus & impaired glucose tolerance (OR = 1.152;

95%CI 1.03–1.91), history of hypertension (OR = 2.763; 95%CI 1.01–7.68) or fatty liver (OR = 1.143; 95%CI 1.03–1.66), family history of cancer in digestive system (OR = 2.626; 95%CI 2.24–3.08), LDL (OR = 2.086; 95%CI 1.15–3.79), high-sensitivity

C-reactive protein (hsCRP, OR = 3.269; 95%CI 1.75–6.12) were the risk factors of colorectal adenoma, while female (OR = 0.197; 95%CI 0.06–0.67) and daily fiber intake (OR = 0.730; 95%CI 0.62–0.85) were the protective factors. Conclusion: The risk factors of colorectal adenoma included BGB324 clinical trial abdominal circumference, daily calories & fat intake, increased diastolic blood pressure, diabetes mellitus & impaired glucose tolerance, history of hypertension or fatty liver, family history of cancer in digestive system, LDL and hsCRP, while female and daily fiber intake were the protective factors of colorectal adenoma. Key Word(s): 1. Colorectal Adenoma; 2. Risk Factor; 3. Case-Control Study; Presenting Author: XIN HAIWEI Additional Authors: ZHU LIMING, MIN CHANG, check details FEI GUIJUN, SUN XIAOHONG, LI XIAOQING, ZHANG MING, SUN GANG, WANG ZHIFENG, KE MEIYUN, FANG XIUCAI Corresponding Author: FANG XIUCAI Affiliations: Peking Union Medical College Hospital Objective: Patients with irritable bowel syndrome with diarrhea (IBS-D) presented arbitrary symptoms with alternation of onset and remission, or persistence. The aims of this study were to compare the colonic motility

and mucosal enterochromaffin cells (EC) in IBS-D patients during the period of symptom onset, remission and persistence. Methods: Colonic manometry was administrated for 2 hours in fasting and 3 hours in postprandial status. The mucosal biopsies from sigmoid colon were obtained to detect ECs by immunohistochemical staining with 5-HT. Onset indicates patients having typical IBS symptoms in three days, remission means being asymptomatic for more than ten days, persistence indicates having symptoms for more than 2/3 of days in last three months. Results: Thirty two subjects completed the colon manometry (eight in each group). In fasting phase, the quantity of high amplitude propulsive contractions (HAPCs) and low amplitude propulsive contractions (LAPCs) and motility index (MI) for patients in onset group were higher than remission, persistence and healthy groups (P = 0.019, P = 0.000, P = 0.001).