The DNA binding domain, preventing expression of DNA repair proteins (blue frame) and the peptidase S24-like domain, catalyzing self-cleavage of LexA (green frame) are indicated as well as conserved bases involved in the LexA repressor cleavage Gamma-secretase inhibitor reaction (A84-G85 cleavage bond, S119 nucleophile, basic K156; red frame; [80]. Sequence

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