\n\nResults\n\nFST was better correlated to MED than to MMD, and FST correlated better to constitutive than to facultative pigmented areas after multiple exposures rather than to a single exposure. PPF was generally much better correlated to MED and MMD than FST especially after a single exposure and multiple exposures with steady-state pigmentation.\n\nMultiple regression analyses showed that MED was the only significant, or most important determinator, of both FST and PPF. The correlation coefficient was highly significant for PPF (r2=82).\n\nConclusions\n\nPPF is a better predictor of the individual UV sensitivity (linear relation) than FST (only 4 grades) and PPF can

substitute FST.”
“A growing number of poorly water-soluble drug have been discovered, but the poor bioavailability is a critical problem. In this study, physical CHIR98014 PI3K/Akt/mTOR inhibitor properties and dissolution profiles of cilostazol

solid dispersions prepared by hydrophilic/lipophilic Dibutyryl-cAMP excipients (Kollidon (R) VA64, tocopheryl polyethylene glycol succinate (TPGS), vitamine E) with hot-melt and thermal adhesion granulation (TAG) method to adsorb Fujicalin (R) and Microcel (R) were characterized. Results demonstrate the angle of repose in formulations with Fujicalin (R) was improved than those with Microcel (R), but the difference disappeared when more TPGS or vitamin E was added. Compared the formulation made by hot-melt and TAG method, both improved flowability. The hardness decreased with the increased Selleck GSK1120212 amount of TPGS and vitamin E. The formulations with Microcel (R) had lower hardness than those with Fujicalin (R), because Microcel (R) has weaker adsorption ability and cannot afford much TPGS and vitamin E, leading to lower hardness. Furthermore, the solubility

was almost three-fold higher than that of Pletaal (R) (7.68 +/- 0.20 mu g/mL) in compositions containing TPGS and vitamin E made by hot-melt or TAG method, in which a controlled drug release pattern was demonstrated. There is no significant difference on dissolution profile between hot-melt and TAG method. However, the procedure of TAG is easier, indicating its potential pharmaceutical use. (C) 2014 Elsevier B.V. All rights reserved.”
“Aims Experience in the use of whole slide imaging (WSI) for primary diagnosis in pathology is very limited. We aimed to determine the accuracy of interpretation of WSI compared with conventional light microscopy (CLM) in the diagnosis of routine gynaecological biopsies. Methods All gynaecological specimens (n=452) received over a 2-month period at the Department of Pathology of the Hospital Clinic of Barcelona were analysed blindly by two gynaecological pathologists, one using CLM and the other WSI. All slides were digitised in a Ventana iScan HT (Roche diagnostics) at 200x.