\n\nResults\n\nAnalysis of the interviews selleck products suggested that the use of severity questionnaires

posed an intrusion into the consultation. GPs discursively polarised two technologies: formal assessment versus personal enquiry, emphasising the need to ensure the scores are used sensitively and as an aid to clinical judgement rather than as a substitute. Importantly, these challenges implicitly served a function of preserving GPs’ identities as professionals with expertise, constructed as integral to the process of diagnosis.\n\nConclusion\n\nGP accounts indicated concern about threats to patient care. Contention between using severity questionnaires and delivering individualised patient care is significantly motivated by GP concerns to preserve professional expertise and identity. It is important to learn from GP concerns to help establish how best to optimise the use of severity questionnaires in depression.”
“Background: Bartonella henselae was discovered a quarter of a century ago as the causative agent of cat-scratch disease. More recently, Bartonella has been found to be responsible for a broad range of clinical syndromes (prolonged fever, hepatosplenic disease, encephalopathies, ocular disease) and associated with autoimmune conditions. Case: This is the first report of autoimmune thyroiditis related

to B. henselae infection. We describe an 11-year-old boy who presented with goiter and weight Rabusertib inhibitor loss. At the time of admission a 2 x 1 cm mildly tender right supraclavicular lymph node was noted in association with an erythematous papule at the same

side of the neck. We describe an association of autoimmune hyperthyroidism (Hashitoxicosis) with B. henselae infection (cat-scratch disease) in a pediatric patient. Conclusion: Different types of infections are implicated in the pathogenesis of autoimmune thyroid disease through molecular mimicry or other mechanisms, despite their role is disputed. We speculated that autoimmune thyroiditis should be added Proteasome inhibitor to the spectrum of clinical syndromes that can be triggered by B. henselae. Copyright (c) 2013 S. Karger AG, Basel”
“Cryptococcus neoformans is an opportunistic fungal pathogen that causes lung inflammation and meningoencephalitis in immunocompromised people. Previously we showed that mice succumb to intranasal infection by induction of pulmonary interleukin (IL)-4R alpha-dependent type 2 immune responses, whereas IL-12-dependent type 1 responses confer resistance. In the experiments presented here, IL-4R alpha(-/-) mice unexpectedly show decreased fungal control early upon infection with C. neoformans, whereas wild-type mice are able to control fungal growth accompanied by enhanced macrophage and dendritic cell recruitment to the site of infection. Lower pulmonary recruitment of macrophages and dendritic cells in IL-4R alpha(-/-) mice is associated with reduced pulmonary expression of CCL2 and CCL20 chemokines.