Only one-fifth were ranked “”superior”" for ease of use and comprehensibility.
Conclusions: Most written materials have a readability level that is too high and require improvement in ease of use and comprehensibility for the majority of readers.”
“Treatment with antitumor necrosis factor-alpha (anti-TNF-alpha) offers a significant improvement in several immune-based diseases,
selleck chemicals including Crohn’s disease (CD) and psoriasis. Different cutaneous side effects have been described for anti-TNF-a therapy such as psoriasis. Previous reports showed that inhibition of TNF-alpha can induce over expression of cutaneous IFN-alpha, which in turn caused a predisposition to psoriasis. We report a 31-year-old woman with extensive CD and perianal lesions, without response to conventional treatment. She paradoxically developed a cutaneous GSK1120212 cost eruption with psoriasiform morphology and distribution during treatment with both anti-TNF-alpha approved in Europe for CD, infliximab and adalimumab. These lesions cleared after topical application of corticosteroids and cessation of the anti-TNF-alpha treatment. Due to uneffectiveness of pharmacological treatment on disease, the patient had to undergo surgery. TNF-induced psoriasis in patients with CD is rare and has been previously
documented with infliximab or adalimumab. The reason for this apparently paradoxical effect of the therapy is still unclear. This is the first case of psoriasis induced first by infliximab and later by adalimumab in the same CD patient. We would like to review and to draw attention about psoriasis SN-38 mouse as a cutaneous side effect with anti-TNF-a treatments. (C) 2010 European Crohn’s and Colitis Organisation. Published by Elsevier B.V. All rights reserved.”
“Background: In a low socioeconomic-status population of Latina women, we evaluated the potential of storytelling (ST) as a culturally aligned narrative method to promote colorectal cancer (CRC) prevention and screening, compared to a risk tool (RT)-based intervention.
Methods: Seventy-eight women
were randomized in this pilot study to one of two brief interventions to communicate CRC risk reduction options: ST or an RT. Measures of behavioral intentions relative to CRC prevention and screening were obtained following the intervention.
Results: Mean scores for intent to obtain and recommend endoscopy to others were significantly better for participants receiving ST than RT (P = .038 and P = .011, respectively). All participants expressed intent to increase fruit and vegetable consumption and physical activity in response to interventions. Post-intervention perceptions of cancer risk and fear of CRC were not significantly different for participants receiving ST compared with RT. Pre- to post-intervention perceptions of risk increased in ST and decreased in RT, while decreases in fear were similar across both intervention groups.