Nevertheless, most of the previous studies were small, hence insufficiently powered to answer this question.27 One also has to consider that the absence of association between menopausal status and risk for diabetes may be due to the majority of women inhibitor Vandetanib being already post-menopausal at the time of onset of diabetes

in this study. Some limitations of this study must be taken into consideration. As in most population-based studies, the presence of diabetes mellitus was determined on the basis of self-reported physician-diagnosed diabetes, and confirmation of this diagnosis was not made. Nevertheless, the onset of a disease so important like diabetes is generally remembered, which decreases the risk of remembering bias.28 It was also not possible to consider all of the factors that can impact the risk of the onset of diabetes like health problems, gestational diabetes and dietary intake or type of foods consumed.29 Furthermore, in this study, the age of the occurrence of diabetes was also based on the report of the diagnosis made by the physician and other degrees of abnormal glucose tolerance were not taken into account.

The reliability of self-reported diabetes mellitus has been previously validated.2 The fact of the study having a population-based nature represents an important strongpoint. The representativeness of the population sample allows these conclusions to be extrapolated to the entire population of women aged 50 years or more in a Brazilian city. Population-based estimates of the age of occurrence of diabetes in women aged 50 years or more and its associated factors are important for understanding this issue in women’s lives as they age, while designing interventions in the field of diabetes prevention requires good knowledge of region-specific trends. Conclusions Self-rated health considered good or very good was associated with a higher rate of survival

without diabetes. Sharing a home with two or more other people and a weight increase at 20–30 years of age was associated with the onset of type 2 diabetes. These results contribute to highlighting the need to target weight control Anacetrapib interventions earlier in life and for measures aimed to improve women’s socioeconomic conditions during the ageing process to prevent type 2 diabetes. Supplementary Material Author’s manuscript: Click here to view.(1.1M, pdf) Reviewer comments: Click here to view.(138K, pdf) Footnotes Contributors: AMP-N, VSSM and ALRV contributed to the conception and design of this study. VSSM and AMP-N were involved in the acquisition of data. MHdS, AMP-N and ALRV contributed to the analysis and interpretation of data. ALRV, AMP-N and LCP were involved in the drafting of the article and ALRV, MP-N, LCP, MHdS and VSSM in revising it for intellectual content.