N Engl J Med 344:1434–1441PubMedCrossRef 2. Orwoll ES, Scheele WH, Paul S, Adami S, Syversen U, Diez-Perez A, Kaufman JM, Clancy AD, Gaich GA (2003) The effect of teriparatide
[human parathyroid hormone (1–34)] therapy Tozasertib nmr on bone density in men with osteoporosis. J Bone Miner Res 18:9–17PubMedCrossRef 3. Kurland ES, Cosman F, McMahon DJ, Rosen CJ, Lindsay R, Bilezikian JP (2000) Parathyroid hormone as a therapy for idiopathic osteoporosis in men: effects on bone mineral density and bone markers. J Clin Endocrinol Metab 85:3069–3076PubMed 4. Nakamura T, Sugimoto T, Bucladesine Nakano T, Kishimoto H, Ito M, Fukunaga M, Hagino H, Sone T, Yoshikawa H, Nishizawa Y, Fujita T, Shiraki M (2012)
Randomized teriparatide [human parathyroid hormone (PTH) 1–34] once-weekly efficacy research (TOWER) Caspase Inhibitor VI trial for examining the reduction in new vertebral fractures in subjects with primary osteoporosis and high fracture risk. J Clin Endocrinol Metab 97:3097–3106PubMedCrossRef 5. Miyauchi A, Matsumoto T, Sugimoto T, Tsujimoto M, Warner MR, Nakamura T (2010) Effects of teriparatide on bone mineral density and bone turnover markers in Japanese subjects with osteoporosis at high risk of fracture in a 24-month clinical study: 12-month, randomized, placebo-controlled, double-blind and 12-month open-label phases. Bone 47:493–502PubMedCrossRef 6. Glover SJ, Eastell R, McCloskey EV, Rogers A, Garnero P, Lowery J, Belleli R, Wright TM, John MR (2009) Rapid and robust SPTBN5 response of biochemical markers of bone formation to teriparatide therapy. Bone 45:1053–1058PubMedCrossRef 7. Shiraki M, Sugimoto T, Nakamura T (2013) Effects of a single injection of teriparatide on bone turnover markers in postmenopausal women. Osteoporos Int 24:219–226PubMedCentralPubMedCrossRef 8. Teitelbaum AP, Silve CM, Nyiredy KO, Arnaud CD (1986) Down-regulation of parathyroid hormone (PTH) receptors in cultured bone cells is associated with agonist-specific
intracellular processing of PTH-receptor complexes. Endocrinology 118:595–602PubMedCrossRef 9. Yamamoto I, Shigeno C, Potts JT Jr, Segre GV (1988) Characterization and agonist-induced down-regulation of parathyroid hormone receptors in clonal rat osteosarcoma cells. Endocrinology 122:1208–1217PubMedCrossRef 10. Mahoney CA, Nissenson RA (1983) Canine renal receptors for parathyroid hormone: down-regulation in vivo by exogenous parathyroid hormone. J Clin Invest 72:411–421PubMedCentralPubMedCrossRef 11. González EA, Martin KJ (1996) Coordinate regulation of PTH/PTHrP receptors by PTH and calcitriol in UMR 106–01 osteoblast-like cells. Kidney Int 50:63–70PubMedCrossRef 12.