METHODS
We conducted a double-blind, placebo-controlled, randomized trial to assess the effect of subcutaneous enoxaparin (40 mg daily) as compared with placebo – both administered for 10 +/- 4 days in patients who were wearing elastic stockings with graduated compression – on the rate of death from any cause among hospitalized, acutely ill medical patients at participating sites in China, India, Korea, Malaysia, Mexico, the Philippines, and Tunisia. Inclusion criteria were an age selleck compound of at least 40 years and hospitalization for acute decompensated heart failure,
severe systemic infection with at least one risk factor for venous thromboembolism, or active cancer. The primary efficacy outcome was the rate of death from any cause at 30 days after randomization. The primary safety outcome was the rate of major bleeding AZD2014 price during and up to 48 hours after the treatment period.
RESULTS
A total of 8307 patients were randomly
assigned to receive enoxaparin plus elastic stockings with graduated compression (4171 patients) or placebo plus elastic stockings with graduated compression (4136 patients) and were included in the intention-to-treat population. The rate of death from any cause at day 30 was 4.9% in the enoxaparin group as compared with 4.8% in the placebo group (risk ratio, 1.0; 95% confidence interval [CI], 0.8 to 1.2; P=0.83). The rate of major bleeding was 0.4% in the enoxaparin group and 0.3% in the placebo group (risk ratio, 1.4; 95% CI, 0.7 to 3.1; P=0.35).
CONCLUSIONS
The use of enoxaparin plus elastic stockings with graduated compression, as compared with elastic stockings with graduated compression alone, was not associated with a reduction in the rate of death from any cause among
hospitalized, acutely ill medical patients. (Funded by Sanofi; LIFENOX ClinicalTrials.gov number, NCT00622648.)”
“Purpose: Sexual dysfunction has been associated with pelvic fractures, especially in patients with concomitant urethral injuries. A critical review of the existing literature was performed focusing on the reported definitions CP673451 of sexual dysfunction, its reported incidence, the presence of related risk factors, the methods of assessing sexual function, the timing of this assessment and its management.
Materials and Methods: The PubMed (R) search engine was used in July 2010 to retrieve articles using the terms “”pelvic fracture”" and “”sexual function”" in their title or abstract, published in the English language, from 1989 onward. The references of the selected publications were also evaluated for potential relevant studies according to set selection criteria.
Results: Based on 23 original articles the data of 1,462 patients, with a mean age of 37.7 years (range 15 to 92), were analyzed. The overall mean reported incidence of sexual dysfunction was 35.9% in men and 39.6% in women.