Libert – Employment: Gilead Sciences Christiane Stern – Employment: Gilead Sciences Patrick Marcellin – Consulting: Roche, Gilead, BMS, Vertex, Novartis, Janssen-Tibotec, MSD, Boehringer, Pfizer, Abbott, Alios BioPharma; Grant/Research Support: Roche, Gilead, BMS, Novartis, Janssen-Tibotec, INK 128 concentration MSD, Alios BioPharma; Speaking and Teaching: Roche, Gilead,

BMS, Vertex, Novartis, Janssen-Tibotec, MSD, Abbott The following people have nothing to disclose: Denis Ouzan, Thierry Fontanges, Jean Didier Grange, Jean françois D. Cadranel Background/Aims: Liver stiffness (LS) values using LDK378 transient elastography provides accurate assessment of liver fibrosis in patients with chronic liver disease. The influence of antiviral treatment using entecavir (ETV) on LS values was assessed in patients with chronic hepatitis B (CHB). Methods: One hundred and twenty-one NUC-naïve

patients with CHB who completed 3-year ETV treatment at the end of follow-up (April 201 3) were evaluated. LS was measured at the start and completion MCE of the 3-year ETV treatment. The aim of this study was to evaluate the change in LS value under ETV therapy, and the presence of a decrease in LS value >1 kPa from the baseline. Results: The mean baseline LS value of the patients was 1 8.0 kPa. During the 3-year ETV treatment, the mean LS values decreased significantly from 18.0 to

9.3 kPa (P<0.001). In univariate analyses, the absence of diabetes mellitus, higher HBV DNA level, normalization of alanine aminotransferase (ALT) during the study period, and higher baseline LS values were associated with a LS decrease in LS values >1 kPa (all P<0.05). Together with ALT normalization, multivariate analysis identified higher baseline LS values as an independent predictor of a decrease of LS values >1 kPa (P<0.001; hazard ratio [HR], 1.235; 95% confidence interval [CI], 1.104-1.382). Using the optimal cutoff baseline LS value of 10 kPa (area under receiver operating characteristic curve=0.835; 95% CI, 0.732-0.937, P<0.001; sensitivity 76.5%; specificity, 73.