Kidney Int. 2003;64:149–59.PubMedCrossRef 27. Ye M, Wysocki J, William J, Soler MJ, Cokic I, Batlle D. Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes. J Am Soc Nephrol. 2006;17:3067–75.PubMedCrossRef Metabolism inhibition 28. Wagner J, Gehlen F, Ciechanowicz A, Ritz E. Angiotensin II receptor type 1 gene expression
in human glomerulonephritis and diabetes mellitus. J Am Soc Nephrol. 1999;10:545–51.PubMed 29. Suzuki K, Han GD, Miyauchi N, Hashimoto T, Nakatsue T, Fujioka Y, et al. Angiotensin II type 1 and type 2 receptors play opposite roles in regulating the barrier function of kidney glomerular capillary wall. Am J Pathol. 2007;170:1841–53.PubMedCrossRef 30. Takamatsu M, Urushihara M, Kondo S, Shimizu M, Morioka T, Oite T, et al. Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy. Pediatr Nephrol. 2008;23:1257–67.PubMedCrossRef 31. Arai M, Wada A, Isaka Y, Akagi Y, Sugiura T, Miyazaki M, et al. In vivo transfection of genes for renin and angiotensinogen into the glomerular cells induced phenotypic change of the mesangial cells and glomerular sclerosis. Biochem Biophys Res Commun. 1995;206:525–32.PubMedCrossRef 32. Shi L, Nikolic D, Liu S, Lu H, Wang S. Activation of renal renin-angiotensin system in upstream stimulatory
factor 2 transgenic mice. Am Temsirolimus in vivo J Physiol Ren Physiol. 2009;296:F257–65.CrossRef ADAMTS5 33. Singh R, Singh AK, Leehey DJ. A novel mechanism for angiotensin II formation in streptozotocin-diabetic rat glomeruli. Am J Physiol Ren Physiol. 2005;288:F1183–90.CrossRef 34. Lee LK, Meyer TW, Pollock AS, Lovett DH. Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney. J Clin Invest. 1995;96:953–64.PubMedCrossRef 35. Kagami S, Border WA, Miller DE, Noble NA. Angiotensin II stimulates extracellular matrix protein synthesis through Crenolanib ic50 induction of transforming growth factor-beta expression in rat glomerular mesangial cells. J Clin Invest. 1994;93:2431–7.PubMedCrossRef
36. Kagami S, Kuhara T, Okada K, Kuroda Y, Border WA, Noble NA. Dual effects of angiotensin II on the plasminogen/plasmin system in rat mesangial cells. Kidney Int. 1997;51:664–71.PubMedCrossRef 37. Kondo S, Shimizu M, Urushihara M, Tsuchiya K, Yoshizumi M, Tamaki T, et al. Addition of the antioxidant probucol to angiotensin II type I receptor antagonist arrests progressive mesangioproliferative glomerulonephritis in the rat. J Am Soc Nephrol. 2006;17:783–94.PubMedCrossRef 38. Urushihara M, Takamatsu M, Shimizu M, Kondo S, Kinoshita Y, Suga K, et al. ERK5 activation enhances mesangial cell viability and collagen matrix accumulation in rat progressive glomerulonephritis. Am J Physiol Ren Physiol. 2010;298:F167–76.CrossRef 39. Kinoshita Y, Kondo S, Urushihara M, Suga K, Matsuura S, Takamatsu M, et al.