J Clin Pathol 2005, 58:202–206.PubMedCrossRef 35. Williams CS, Leek RD, Robson AM, Banerji S, Prevo R, Harris AL, Jackson DG: Absence of lymphangiogenesis and intratumoural lymph vessels in human LDN-193189 metastatic breast cancer. J Pathol 2003, 200:195–206.PubMedCrossRef 36. Kyzas PA, Geleff S, Batistatou A, Agnantis NJ, Stefanou D: Evidence for lymphangiogenesis and its prognostic implications in head and neck squamous cell carcinoma. J Pathol 2005, 206:170–177.PubMedCrossRef 37. Inoue A, Moriya H, Katada N, Tanabe S, Kobayashi N, Watanabe M, Okayasu I, Ohbu M: Intratumoral lymphangiogenesis of esophageal squamous cell carcinoma and relationship with regulatory factors
and rognosis. Pathol Int 2008, 58:611–619.PubMedCrossRef 38. Mahendra G, Kliskey K, Williams K, Hollowood K, Jackson D, Athanasou NA: Intratumoural lymphatics in benign and malignant soft tissue tumours. Virchows Arch 2008, 453:457–464.PubMedCrossRef 39. Karpanen T, Alitalo K: Molecular biology and pathology of lymphangiogenesis. Annu Rev Pathol 2008, 3:367–397.PubMedCrossRef 40. Yanai Y, Furuhata T, Kimura Y: Vascular endothelial growth factor C promotes human gastric carcinoma lymph node metastasis in mice. J Exp Clin Cancer Res 2001, 20:419–428.PubMed 41. Mäkinen T, Jussila L, Veikkola T, Karpanen T, Kettunen
MI, Pulkkanen KJ, Kauppinen R, Jackson DG, Kubo H, Nishikawa S, Ylä-Herttuala S, Alitalo K: Inhibition of lymphangiogenesis selleck products with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. Nat Med 2001, 7:199–205.PubMedCrossRef 42. Wirzenius M, Tammela T, Uutela M, He Y, Odorisio T, Zambruno G, Nagy JA,
Dvorak HF, Yl-Herttuala S, Shibuya M, Alitalo K: Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting. J Exp Med 2007, 204:1431–1440.PubMedCrossRef 43. Liu P, Chen W, Zhu H, Liu B, Song GBA3 S, Shen W, Wang F, Tucker S, Zhong B, Wang D: Expression of VEGF-C Correlates with a Poor Prognosis. Based on Analysis of Prognostic Factors in 73 Patients with Esophageal Squamous Cell Carcinomas. Jpn J Clin Oncol 2009,39(10):644–650.PubMedCrossRef 44. Miyahara M, Tanuma J, Sugihara K, Semba I: Tumor lymphangiogenesis correlates with lymph node metastasis and clinicopathologic parameters in oral squamous cell carcinoma. Cancer 2007, 110:1287–1294.PubMedCrossRef 45. Arinaga M, Noguchi T, Takeno S, Chujo M, Miura T, Uchida Y: selleck screening library Clinical significance of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in patients with nonsmall cell lung carcinoma. Cancer (Phila) 2003, 97:457–464.CrossRef 46. Möbius C, Freire J, Becker I, Feith M, Brücher BL, Hennig M, Siewert JR, Stein HJ: VEGF-C expression in squamous cell carcinoma and adenocarcinoma of the esophagus. World J Surg 2007, 31:1768–1774.PubMedCrossRef 47. Ristimaki A, Honkanen N, Jankala H, Sipponen P, Harkonen M: Expression of cyclooxygenase-2 in human gastric carcinoma. Cancer Res 1997, 57:1276–1287.PubMed 48.