In this totally noninvasive method, the pH dependence of the chemical exchange between amide protons in endogenous proteins and peptides and water protons is exploited. Early results in animal models of ischemia show promise to derive an acidosis

penumbra. Possible translation to the clinic and hurdles standing in the way of achieving this are discussed.”
“Background. There are controversial results regarding the endothelial function in patients with white coat hypertension (WCH). The aim of this study was to assess endothelial function measuring nitric oxide (NO) and C-reactive protein (CRP) level in WCH and to compare those with essential hypertension (EH) and healthy subjects. Methods. The 40 newly diagnosed buy BAY 80-6946 patients with EH, 40 patients with WCH and 40 healthy volunteers were included to study. Plasma CRP levels were measured by immunonephelometery method. Plasma NO level was also detected by using the Griess method. Results. Plasma CRP level was significantly higher in patients with find more EH when compared with those with WCH and healthy subjects (6.3 +/- 2.1 mg/l, 2.1 +/- 0.9 mg/l and 1.6 +/- 1.3 mg/l, p < 0.05, respectively). However, there was no signifi cant difference with respect to CRP level between those with WCH and healthy subjects. NO level was significantly lower in patients with EH when compared with those with WCH and healthy subjects (4.6 +/- 1.1 mu mol/l,

6.9 +/- 1.2 mu mol/l and 8.1 +/- 1.5 mu mol/l, p < 0.05, respectively). There was no signifi cant difference with respect to NO level between those with WCH and healthy subjects. Plasma CRP level was positively correlated with office, daytime, night-time and 24-h blood pressure values, whereas NO level was inversely correlated with these parameters. Plasma CRP level was also inversely correlated with NO level. Conclusions. Our data suggest that CRP concentration is significantly higher

and NO level is meaningfully lower in patients with essential hypertension when compared with those with WCH and controls. This may suggest that endothelial functions are preserved in patients with WCH in contrast to essential hypertension.”
“Objective: GDC-0994 It was to evaluate the relationships between fatigue and excessive daytime sleepiness, sleep quality, depression and anxiety. Methods: This was a cross-sectional study on 98 unselected adult patients with epilepsy (PWE) at a tertiary center. It used clinical-sociodemographic characteristics, fatigue measured by the SF-36 vitality subscale (VsSF-36) and the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index and Beck Depression and Anxiety Inventories. Results: We observed that our patients presented vitality or fatigue similar to drivers with chronic headaches evaluated in the same city. Fatigue was related to depression, anxiety and sleep quality, but not to daytime sleepiness.