health economic evaluations taking into consideration the growth of new onset diabetes must be conducted for different classes of antihypertensive agents. Keywords: diabetes mellitus, type 2, hypertension, Angiotensin converting enzyme inhibitors, Angiotensin II type receptor blockers, Anastrozole molecular weight calcium channel blockers, diuretics Summary Health political back ground Expenses within the statutory health insurance continuously increase because of medical improvement and the demographic growth. Because of the increase in health care expenditures it’s requested to keep costs down especially for drugs. Thus, therapeutic techniques which are cost effective in the short term along with in the long term must be promoted. Particularly chronic diseases substantially contribute to the constant escalation in healthcare expenditures, including diabetes mellitus as you of the very most expensive chronic diseases. Arterial hypertension in addition to obesity and adiposity current risk factors for the development of Metastasis diabetes mellitus. Hypertension and diabetes mellitus often appear in combination. Numerous studies have demonstrated that not just hypertension, but also antihypertensive therapies promote the development of type 2 diabetes mellitus. Studies show the application of angiotensin converting enzyme inhibitors and angiotensin receptor blockers lead to less new onset diabetes when compared with diuretics, betablockers and placebo. Considering that beta blockers and diuretics impair the glucose kcalorie burning, the metabolic consequences of different antihypertensive drugs ought to be regarded, supplier Tipifarnib otherwise not only the disease itself, but in addition antihypertensive therapies may encourage the development of new onset diabetes. The employment in patients with metabolic disorders could be cost effective in the long term if new on-set diabetes is avoided, even though the cost of ACE inhibitors and ARB are higher. Scientific history Hypertension is a risk factor for arteriosclerotic vascular disorders. Cohort studies in the 1970ies and 1980ies in addition to within the 1990ies show, that both systolic and diastolic blood pressure correlate with the danger of stroke and coronary artery disease. World wide, hypertension is responsible for more than 50% of deaths due to stroke and for about 25 percent of deaths due to coronary artery disease. The prevalence reduced in the last decade but is still large and will most likely increase because of demographic development: elderly people in many cases are more suffering from hypertension than younger people. The entire life risk for developing hypertension is nearly 90% for people more than 55 years old. Moreover, the prevalence of adiposity also associated with hypertension, keep on to improve in the industrial nations. The rate of new onset diabetes differed in the reports because they were sometimes along with other antihypertensive drugs and no monotherapy was considered.