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“Background Tetanus, though a vaccine preventable disease, is still a significant public health problem throughout the world and it is associated with a high learn more morbidity and mortality rate, particularly in the developing world [1–3]. The global incidence of tetanus is still estimated at one million cases annually, with a case fatality ratio ranging from 6% to 72% depending on the availability of well equipped intensive care unit [3]. The incidence selleckchem of tetanus in the developed world is markedly low and is no longer responsible for significant mortality, this has been attributed to high level of health

awareness in terms of vaccination and availability of human and material resources to manage the disease [4]. In developed countries tetanus occurs mainly in elderly due to decline in protective antibodies [5, 6] and in developing countries tetanus is common in the young due to lack of effective immunization program and appropriate treatment of injuries [4, 7]. Tetanus is caused by Clostridium Tetani, a gram positive, anaerobic and spore forming bacterium which is found in soil and in animal and human faeces and the usual mode of entry is through a punctured wounds or lacerations, although tetanus may follow surgery, burns, gangrene, chronic ulcers, dog bites, injections such as with drug users, dental infection, abortion and childbirth [3, 8]. In some patients no portal of entry for the organism can be identified [5, 8].