Cellular atypia and diminished reticulin fibers around the hepatic column were not observed. A survey

of the background livers of 13 patients with cavernous hemangioma disclosed similar hemangioma-like vessels in hepatic parenchyma in six patients (46%), but similar nodular lesions were not detected in any patients. Taken together, the hepatic lesions in these two patients may be hither-to unrecognized types of hyperplastic hepatocellular lesion associated with localized hemangiomatous lesion that may cause irregular blood flow. Hypervascular hepatocellular Ixazomib price lesions include hepatocellular carcinoma (HCC), hepatocellular adenoma, focal nodular hyperplasia (FNH) and FNH-like nodule.[1-6] Differential diagnosis between HCC and other

benign nodules is important and occasionally difficult.[6] The recent progress of imaging modalities including computed tomography (CT) and magnetic resonance imaging (MRI) with various enhancements, such as gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced (EOB), contribute to make the differential diagnosis among these hypervascular hepatic nodules.[6-8] Hepatocellular carcinoma usually arises in chronic advanced liver disease due to viral hepatitis B and C, chronic alcoholism and non-alcoholic fatty liver disease. Hepatocellular adenoma is a benign hypervascular hepatocellular neoplasm. Recent progress in the molecular analysis of hepatocellular adenoma revealed subtypes of hepatocellular Kinase Inhibitor Library adenoma[1-5] that can be diagnosed by immunostaining for liver fatty acid binding protein (LFABP), glutamine synthetase (GS) and serum amyloid A (SAA).[1-5] FNH is a benign hepatocellular hyperplastic lesion usually associated with abnormal vessels, such as abnormal thickened

arteries, and half of them have a central stellate scar.[1] Irregular blood flow due to abnormal vessels is thought to cause hyperplasia of hepatic parenchyma.[1] Furthermore, several studies have demonstrated a hypervascular liver nodule showing similar imaging findings to HCC; so-called FNH-like nodules.[7, 9, 10] We have recently reported that some selleck compound FNH-like nodules in patients with alcoholic cirrhosis share histological and immunohistochemical features with inflammatory hepatocellular adenoma and refer to them as “SAA-positive hepatocellular neoplasms”.[11] Hepatic hemangioma is the most common benign mesenchymal tumor with an estimated prevalence of 0.4–20%, which is also detected as a hypervascular lesion of the liver on imaging.[6, 12, 13] It is thought that a part of hepatic hemangiomas may be anomalous lesions, not true neoplastic lesions.[6, 12-14] It is usually a well-circumscribed lesion with a distinct fibrous interface of less than 2 cm in diameter and is located under the hepatic capsule. Cavernous accumulation of vessels is seen and sometimes organization and sclerosis are associated.