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“Purpose: Postoperative prostate specific antigen doubling time may be used as a surrogate for prostate cancer specific mortality in patients with biochemical recurrence after radical prostatectomy. Less is known LY2109761 about the usefulness of preoperative prostate specific antigen doubling time for the initial prediction of prostatectomy outcomes.
Materials and Methods: Preoperative
prostate specific antigen doubling time was calculated in 1,208 men from a large prostate cancer screening Selleckchem OSI-744 study who were treated with radical prostatectomy. We examined the relationship of prostate specific antigen doubling time with tumor features and biochemical progression-free survival.
Results: Overall prostate specific antigen doubling time was associated with nonorgan confined disease (OR 0.996, 95% CI 0.992-0.999, p = 0.013) but not with biochemical progression (HR 1.000, 95% CI 0.998-1.001, p = 0.66). Using previously published 18 and 36-month thresholds for prostate specific antigen doubling time
GW4064 mw there was no significant relationship between doubling time and specific adverse pathological features or biochemical progression. Using the concordance index prostate specific antigen doubling
time did not enhance the prediction of biochemical progression beyond that achieved by a model with prostate specific antigen, clinical stage and biopsy Gleason score.
Conclusions: In our series of men with newly diagnosed, clinically localized prostate cancer shorter preoperative prostate specific antigen doubling time was associated with nonorgan confined disease but not with biochemical progression after radical prostatectomy. All calculations of prostate specific antigen kinetics may not be equivalent. Caution should be exercised when using prostate specific antigen doubling time in the pretreatment setting.”
“Previously, we have demonstrated that the vestibulo-cardiovascular reflex was attenuated in rats reared in a 3G environment for 14 days. Because continuous galvanic vestibular stimulation preserved the vestibulo-cardiovascular reflex in rats at 3G. this attenuation might be attributable to a reduction in the phasic Input to the vestibular system.