“Ba0.6Sr0.4TiO3 (BST)/MgO columnar composites are fabricated via the spark plasma sintering (SPS) method. The microstructure, dielectric and tunable properties of columnar composites are investigated. The unmodified BST Curie temperatures with the increase of MgO addition indicate a sufficient suppression of ions interdiffusion between the two phases. The dielectric constant is decreased from 7000 to 3800 when MgO weight ratio is up to 15% while the tunability still stays at high level over 45%. The coefficient of the dielectric nonlinearity beta shows a growing trend with increasing
MgO content. The experimental results are in agreement with the theoretical prediction and confirm that if the composite is fabricated in columnar model, a reduction of dielectric constant without a deterioration of tunability could be achieved, which make them useful for potential tunable device applications in wireless GSK1838705A mouse communication system. (C) 2012 Elsevier Ltd and Techna Group S.r.l. All rights reserved.”
“Molecular docking is an important tool in screening large libraries of compounds to determine the interactions between potential drugs and the target proteins. The molecular docking problem is how to locate a good conformation to dock a ligand to the large molecule. It can be formulated as a parameter optimization problem consisting of a scoring function and a global optimization method. Many docking
methods have been developed with primarily these two parts varying. In this paper, a variety of particle swarm optimization (PSO) variants were introduced to cooperate with the semiempirical free energy force JQ1 price field in AutoDock 4.05. The search ability and the docking accuracy of these methods were evaluated
by multiple redocking experiments. The results demonstrate that PSOs were more suitable than Lamarckian genetic algorithm (LGA). Among all of the PSO variants, FIPS takes precedence over others. Compared with the four state-of-art docking methods-GOLD, DOCK, FlexX and AutoDock with LGA, AutoDock cooperated with FIPS is more accurate. Thus, FIPS is an efficient PSO variant which has promising prospects that can be expected in the application to virtual screening.”
“The protozoan parasite Cryptosporidium infects all major vertebrate groups and causes significant diarrhea selleck inhibitor in humans, with a spectrum of diseases ranging from asymptomatic to life-threatening. Children and immunodeficient individuals are disproportionately affected, especially in developing countries, where cryptosporidiosis contributes substantially to morbidity and mortality in preschool-age children. Despite the enormous disease burden from cryptosporidiosis, no antiprotozoal agent or vaccine exists for effective treatment or prevention. Cryptosporidiosis involving the respiratory tract has been described for avian species and mammals, including immunocompromised humans.