Acknowledgments The DDD study
(of which the Ethics study presented in this paper is part of) is an independent research commissioned by the selleck chemical Health Innovation Challenge Fund [grant number HICF-1009-003], a parallel funding partnership between the Wellcome Trust and the Department of Health. The views expressed in this publication are those of the author(s) and not necessarily those of the Wellcome Trust or the Department of Health. The research team acknowledges the support of the National Institute for Health Research, through the Comprehensive Clinical Research Network. The authors declare no conflicts of interest. Compliance with ethics guidelines The DDD study has UK Research Ethics Committee approval (11/EE/0313 and 10/H0305/83 granted by the Cambridge South REC and GEN/284/12 granted by the Republic of Ireland REC). All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study. Conflict of interest Anna Middleton, Eugene Bragin and Michael Parker declare that they LEE011 chemical structure have no conflicts of interest. Open Access This article is distributed under the terms of the Creative Commons Attribution License
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