, 2012). Certain organophosphate methyl esters in organophosphate compounds allow promutagenic alkylation damage to DNA, which in turn can produce methylation of DNA (Ray and Richards, 2001). In addition, pesticides exposure can also interact with other methylation-related factors, for example, methyl-donor-related dietary factors and genetic predispositions, to confer increased NHL risk. Epigenetic modifications are relative stable over time and may be influenced by the environment. Exposure to pesticides may lead to epigenome modifications. Experimental, clinical, and epidemiological studies of epigenetic changes caused by pesticides exposure have increased our understanding of the

mechanisms of action by which they can modify gene expression. Most of the studies conducted so far click here have been centered on DNA methylation, whereas only a few recent investigations have studied the effects on histone modifications and miRNAs. Many questions remain open, for example if the learn more observed effects may be the result of the exposure either to a single pesticide compound or to a complex mixture of different chemicals. Far from being conclusive, the reported evidences suggest

that epigenetic modifications may be one of the mechanism by which pesticides can have noxious effects on human health. Further studies are warranted to evaluate if epigenetic modifications may act as a causal link between pesticide exposure and health effects,

or rather be a sensitive marker of exposure. The authors state that they have no conflict of interest. This work was support by INAIL Foundation and Lombardy Region Research Contracts UniMi 8614/2006 and UniMi 9167/2007. Dr. Bollati received support from the EU Programme “Ideas” (ERC-2011-StG 28413). “
“This article has been removed: please Depsipeptide mouse see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been removed at the request of the author. This abstract was inadvertently published in the journal when the authors had requested that it should not. “
“This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been removed at the request of the author. This abstract was inadvertently published in the journal when the authors had requested that it should not. “
“This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been removed at the request of the author. This abstract was inadvertently published in the journal when the authors had requested that it should not. “
“This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been removed at the request of the author.