Major complications occurred in 7 patients (3.9%,including 2 peritoneal hemorrhage, 1 symptomatic pleural effusion, 1 septicemia, 1 hemopneumothorax, 1 pneumothorax and 1 worsened jaundice ) following cryoablation and in 6 patients (3.3%, including 2 septicemia, 1 peritoneal hemorrhage, 1 symptomatic pleural effusion, 1 intrahepatic abscess and 1 worsened ascites ) following RFA (P = 0.776). Conclusions: Our

data demonstrated the cryoablation resulted in a significantly lower HCC recurrent rate, although this website both cryoablation and RFA were equally safe and effective with similar 5-year survival rates. (This was a registered clinical trial in China, listed at Clinicaltrial.gov, ID number, 20071203T) Key words: Hepatocellular carcinoma; Cryoablation; Radiofrequency ablation Disclosures: Ke-Qin Hu – Grant/Research Support:

BMS, Gilead, Merck, Vertex, Genentech; Speaking and Teaching: BMS, Gilead, Merck, Vertex, Genentech The following people have nothing to disclose: Chunping Wang, Huaming Wang, Wuwei Yang, Kaiwen Hu, Hui Xie, Wenlin Bai, Zheng Dong, Yinying Lu, Zhen Zeng, Min Lou, Hong Wang, Xudong Gao, Xiujuan Chang, Linjing An, Jianhui Qu, Jin Li, Yongping Yang “
“Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and ranks in the top three causes of cancer deaths in the Asia-Pacific (AP) region.1,2 Hepatitis B and C virus (HBV and HCV) infections are the most common causes of HCC worldwide. Due to the high prevalence of HBV in the AP region, 75% of HCC patients are seen in this region. The incidence of Selleckchem XL765 HCC has been static over the

years in the AP region; however, it is rising in the western world, Japan and Australia due to an epidemic of HCV infections.1,2 The number of patients with HCC is expected to increase by two times over the next two decades.3 Eighty percent of HCCs develop in patients with liver cirrhosis. The annual incidence of HCC in HBV-related cirrhosis varies from 2% to 6%, while in HCV-related cirrhosis it is 3–5%.4 The majority of HCCs are detected at a late stage with high mortality. Thus, the yearly fatality ratio is close to one indicating almost all patients with HCC die within one year. There have see more been significant advances in diagnostic and therapeutic modalities for early HCC. During 1980–1990, detection of early HCC and curative treatment was possible in only 5–10% patients, while this number increased to 30–40% in 1990–2010.1 In a Japanese study,5 it has been shown that in the last three decades there has been an increasing incidence of early stage HCCs, which has led to the potentially curative treatment of these patients. Clinic-based studies from Italy have also shown that there is a decreasing trend in mortality in liver cirrhosis patients with HCC in the last three decades.6 Looking at these data it seems reasonable to have a surveillance program for early detection of HCC.