HVPG-Free and HVPG-IVC had similar ROC curves (AUC: 0.66 and 0.67). HVPG-Free or HVPG-IVC discriminate 2 populations of pts with significantly Selleck HDAC inhibitor different OLT-free survival. The best cutoff value significantly change within either strategy (16 mmHg for HVPG-Free and 18 for HVPG-IVC) in the whole cohort and also when only considering the “discordant” pts. Importantly,
when HVPG-IVC was measured but HVPG-free cutoff was applied, the prognostic value was lost (no significant differences in OLT-free survival in pts with a HVPG-IVC > or below 16mmHg). Conclusions: HVPG-Free or HVPG-IVC, together with MELD, are independent predictors of death/OLT in pts with cirrhosis regardless of FVHP/IVC discrepancy ≥2mmHg. However, the cut-off value for HVPG-IVC is 2mmHg higher than for HVPG- Free and therefore they can not be interchangeable. This is special relevant in patients with large differences among FHVP and IVC. Disclosures: Jaime Bosch – Consulting: Falk, Gilead Science, Norgine, ONO-USA, Intercept pharma, Exalenz, Almirall, Conatus; Grant/Research Support: Gore Juan Carlos
Garcia-Pagan – Grant/Research Support: GORE The following people have nothing to disclose: Gilberto Silva-Junior, Anna Baiges, Fanny Turon, Karina G. Ramirez Ibarra, Tamoxifen mouse Vera Costa Santos, Annalisa Berzigotti, Virginia Hernandez-Gea Background: We have reported the usefulness of measuring the sheer wave velocity (Vs) using Virtual Touch Quantification (VTQ) in diagnosing fibrosis. This VTQ measurements can also be performed in the spleen. Fibrosis developed in liver cirrhosis can lead to portal hypertension, splenomegaly, and collateral circulation. We studied the diagnostic performance of spleen Vs in esophageal and gastric varices. Patients and Methods: 143 patients
who were diagnosed with esophageal and gastric varices using an upper gastrointestinal endoscopy (GIF) (84 male, age 64.8±12.5; 19 HBsAg(+), 86 HCVAb(+), 38 HBsAg(-)/HCVAb(-)) were included. Diagnosis were made according to the General rules for study of portal hypertension in Japan. The diagnostic ability of 上海皓元 liver and spleen Vs, biochemical exam, and Spleen Index (SI) were compared using receiver operating characteristic analysis (ROC). Results: The form of esophageal varies were F0/F1/F2/F3, 58/60/25/0, respectively. Liver Vs were 1.46/2.27/2.47m/s and spleen Vs were 2.58/3.06/3.71m/s, respectively. Liver and spleen Vs were significantly higher with the development of varices (p<0.001). The red color sign (RC) were RC(-)/(+), 122/21, respectively, and liver Vs and spleen Vs according to RC were 1.90/2.36m/s, 2.88/3.59m/s, respectively. The result showed significantly higher Vs in the group that required treatment (p<0.001). The area under ROC (AUROC) for distinguishing F0-1 from F2 for spleen Vs was 0.904, and it showed the highest diagnostic ability. The cut off value was 3.