The developed method was validated as per ICH guidelines. In order to find out the linearity, the concentrations ranging 2-10 mu g/ml for AMB and 64-320 mu g/ml for VAL was used. The squared correlation co-efficient (r(2) value) Stem Cell Compound Library derived from the equation for AMB and VAL was 0.9979 and 0.9994, respectively. The percentage recoveries calculated for AMB and VAL ranges from 96.93 to 99.63 %. The
estimated drug in the tablet formulation was 100.13 % and 99.99 % for AMB and VAL respectively. The results of analysis shows that method can be used for the estimation of AMB and VAL in the tablet dosage form without further separation in the quality control laboratories.”
“A 52-year-old woman with pulmonary sarcoidosis on immunosuppressive therapy developed pulmonary infiltrates and cutaneous granulomatous abscesses after a trip to the USA in April 2005. A hyphomycete was identified, SC79 concentration further characterized by a gene probe as Coccidioides spp. and then definitively identified as Coccidioides posadasii by polymerase chain reaction and sequencing. Antibodies towards Coccidioides spp. were detected. The infection was successfully treated with posaconazole (Noxafil (R)), 2 x 400 mg/d.”
“Objective: (a) To establish whether disease-related, child-related, and physician-related factors are independently associated with specialist referral in young children with recurrent
RTI, and (b) to evaluate whether general practitioners (GPs) follow current guidelines regarding these referrals.
Methods: Electronic GP records of children under 24 month of age, born 2002-2008, were reviewed R406 datasheet for RTI episodes using ICPC codes. Child-related factors were extracted from the prospective WHISTLER birth-cohort in which a considerable part of children had been enrolled. To evaluate guideline adherence, referral data were compared to national guideline recommendations.
Results: Consultations for 2532 RTI episodes
(1041 children) were assessed. Seventy-eight children were referred for recurrent RTI (3.1% of RTI episodes; 7.5% of children). Disease factors were the main determinants of referral: number (OR 1.7 [CI 1.7-1.71) and severity of previous RTI episodes (OR 2.2 [CI 1.6-2.8]), and duration of RTI episode (OR 1.7 [CI 1.7-1.8]). The non-disease factors daycare attendance (OR 1.3 [CI 1.0-1.7]) and 5-10 years working experience as a GP compared with <5 years (OR 0.37 [CI 0.27-0.50]) were also associated. Fifty-seven percent of referrals for recurrent RTI were made in accordance with national guidelines.
Conclusions: Referral of children for recurrent RTI was primarily determined by frequency, severity, and duration of RTIs; the influence of non-disease factors was limited. Just over half of referrals were made in accordance with guidelines. (C) 2013 Elsevier Ireland Ltd. All rights reserved.