“Cu-free Zr-based bulk metallic glasses (BMGs) with high g

“Cu-free Zr-based bulk metallic glasses (BMGs) with high glass-forming ability (GFA) have been discovered in the Zr-Ni-Al-Nb system. The GFA of Zr-Ni-Al alloys can be significantly enhanced by the minor addition of Nb, which increases the glass transition temperature, and lowers the melting and liquidus temperatures. The Zr-Ni-Al-Nb

BMGs have critical sample diameters of 15-20mm as SNS-032 nmr verified by a copper mold casting. They exhibit excellent corrosion resistance in chloride-ion-containing solutions, which is considerably better than that of other known Zr-based BMGs with superhigh GFA. It was revealed that the formation of highly protective Zr-, Al-, and Nb-enriched surface film is responsible click here for the high corrosion resistance. The BMGs also possess high compressive yield strength of 1786-1847 MPa,

large plastic strain of 1.6-3.2%, and a high Poisson’s ratio of 0.365-0.371. (C) 2011 American Institute of Physics. [doi:10.1063/1.3606642]“
“Cardiovascular disease results in more deaths globally than any other ailment. A major contributing factor to its pathology is atherosclerosis; an inflammatory disorder characterized by the development of fibrotic plaques within the arterial walls. Key to the progression of atherosclerosis are macrophages that contribute to plaque development by transforming into lipid-loaded foam cells upon internalization of modified lipoproteins. Accumulation of such foam cells in the arterial wall initiates the formation of fatty streaks that subsequently develop into advanced plaques that are prone to rupture. Clearly, macrophage lipid metabolism and foam cell biology represent a key avenue of research during the ongoing search for novel therapeutic targets that can be used in the clinical intervention of atherosclerosis. In this article, we aim to summarize the current status of research on macrophages, lipid metabolism and gene expression in relation to atherogenesis and both current GSK923295 Cytoskeletal Signaling inhibitor and potential future therapies.”
“Glucosinolates are amino acid-derived secondary metabolites with diverse biological activities dependent on chemical modifications

of the side chain. Five flavin-monooxygenases FMO(GS-OX1-5) have recently been identified as aliphatic glucosinolate side chain modification enzymes in Arabidopsis thaliana that catalyse the generation of methylsulphinylalkyl glucosinolates, which can be hydrolysed to products with distinctive benefits for human health and plant defence. Though the localization of most aliphatic glucosinolate biosynthetic enzymes has been determined, little is known about where the side chain modifications take place despite their importance. Hence, the spatial expression pattern of FMO(GS-OX1-5) genes in Arabidopsis was investigated by expressing green fluorescent protein (GFP) and beta-glucuronidase (GUS) fusion genes controlled by FMO(GS-OX1-5) promoters.

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