Copyright (C) 2013 S. Karger AG, Basel”
“Aim: To examine the feasibility and validity of computerized ambulatory monitoring in drug-dependent women.

Method: 61 women recruited from public Substance abuse treatment centers in Montreal, Canada participated in the current study, 84% of whom reported past 30-day polysubstance use. Mood states, craving, and drug use were assessed by standard clinical instruments and by electronic interviews during 7-days of computerized ambulatory monitoring. Feasibility was assessed by examining compliance with

intensive monitoring and equipment loss. Concurrent validity was assessed by examining the degree of correspondence of ambulatory data on craving, mood, and Substance use with clinic-based assessments of similar constructs.

Result: Participants completed an Selleckchem KU57788 average 80% of all electronic assessments and no data collection devices were lost or stolen. Relationships among mood, stress, consumption, and SB203580 inhibitor craving assessed in the electronic interviews conformed to well-established patterns, and evidence of concurrent validity were found between scores

from standard clinical instruments and similar constructs in daily life. Center for Epidemiological Studies-Depression Scale (CESD) scores were positively related to sad mood reported during the electronic interviews (p = 0.001) and negatively related to happy mood states (p<0.001), explaining approximately 20% of the

variance in each mood state. ASI drug use seventy scores were positively associated with craving (p<0.001) and substance use (p<0.001), and explained 46% and 30% of these outcomes, respectively.

Conclusion: Angiogenesis inhibitor Computerized ambulatory monitoring is a feasible and valid data collection strategy in drug-dependent individuals. (C) 2008 Elsevier Ireland Ltd. All rights reserved.”
“Background: Obstructive sleep apnoea syndrome (OSAS) is a disorder characterized by repeated apnoeic episodes during sleep. Neurocognitive changes secondary to OSAS are likely to occur due to hypoxia in certain brain locations. Advances in magnetic resonance imaging technology, such as diffusion-weighted imaging (DWI), enable non-invasive and accurate identification of OSAS-induced changes. Objective: We aimed to use DWI to investigate changes in the brain secondary to hypoxia in OSAS. Methods: Eighty-eight patients underwent polysomnography and were classified as non-OSAS, mild-moderate OSAS and severe OSAS sufferers. DWI was used to evaluate 14 areas of the brain, and apparent diffusion coefficients (ADCs) were calculated. We investigated whether there were differences in the ADC values in specific areas of the brain between the non-OSAS and OSAS patients. Results: We measured the ADC values of the 68 newly diagnosed OSAS patients (21 mild, 15 moderate and 32 severe) and of 20 healthy controls.